Recent research challenges calorie-reduction to lose weight. The studies are clear you can lose weight on any diet (as all diets are some forms of calorie reduction). Most of the weight loss from a calorie reduction is very unhealthy weight loss which is lean muscle mass. When you lose lean muscle mass your body must slow down metabolism. As a result of slowing down metabolism you now are burning less calories and that is why you gain all the weight back. The r2mprotocol showed safe weight loss 12 x’s faster than any diets and participants gained not lost 6 to 9% lean muscle mass, and a reduction of 33% of lean muscle mass despite not being allowed to exercise.